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KMID : 1142720240270010005
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Annals of Clinical Microbiology
2024 Volume.27 No. 1 p.5 ~ p.5
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Emergence of Vanrija humicola as a pathogen of urinary tract infections in Korea
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Lee Jae-Won
Won Eun-Jeong
Sung Heung-Sup
Kim Mi-Na
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Abstract
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Vanrija humicola, a yeast belonging to Trichosporonaceae, is rarely pathogenic. All cases of isolation of V. humicola were retrospectively reviewed from 2021 to 2023. A total of four V. humicola were isolated from urine samples. Organisms cultured for 5 days at 25°C produced yellow, dry and cerebriform colonies, and were successfully identified as V. humicola using Bruker Biotyper MALDI-TOF. Two recent isolates were resistant to fluconazole, echinocandins, and flucytosine. In all 4 cases, V. humicola was sporadically isolated more than 14 days after admission. One case was presumed to be colonized. Of the other three cases that developed a urinary tract infection (UTI), only one with pancytopenia was treated for UTI by V. humicola with caspofungin, but expired 4 days later. V. humicola has emerged as a drug-resistant fungal pathogen of hospital-acquired UTI. Species identification and antifungal susceptibility testing of this organism are required for critical patients.
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KEYWORD
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Vanrija humicola, urine, culture, infection, antifungal susceptibility
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